5S-(5-氟胞嘧啶)-1,3-氧硫杂环戊烷-2R-甲酸薄荷醇酯 (FCME)

5S-(5-氟胞嘧啶)-1,3-氧硫杂环戊烷-2R-甲酸薄荷醇酯 (FCME) - Names and Identifiers

Name	(2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxylic acid menthyl ester (FCME)
Synonyms	FCME (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2- (1R,2S,5R)-MENTHYL-5(S)-FLUOROCYTOSINE-1-YL-[1,3]-OXATHIOLANE-2R-CARBOXYLATE (2S,5R)-5-Fluoro cytosine-1-yl-1,3-oxathiolane-2- carboxylic acid menthyl ester (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxylic acid menthyl ester (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2- carboxylic acid menthyl ester (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxylic acid menthyl ester (FCME) (1''R,2''S,5''R)-MENTHYL-(2R-5R)-(4-AMINO-2-OXO-2H-5-FLUORO-PYRIMIDIN-1-YL)-[1,3]OXATHIOLANE (5-methyl-2-propan-2-ylcyclohexyl) 5-(4-amino-5-fluoro-2-oxopyrimidin-1-yl)-1,3-oxathiolane-2-carboxylate 5-(4-amino-5-fluoro-2-oxo-1(2h)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester (2R,5S)-5-(4-Amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic Acid,(2S)-Isopropyl-(5R)-methyl-(1R)-cyclohexyl Ester [1R-[1(2S,5R),2Beta,5Alpha]]-5-(4-Amino-5-Fluoro-2-Oxo-1(2H)-Pyrimidinyl)-1,3-Oxathiolane-2-Carboxylic Acid 5-Methyl-2-(1-Methylethyl)Cyclohexyl Ester [1R-[1(2S,5R),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester [1r-[1(2s,5r),2beta,5alpha]]-5-(4-amino-5-fluoro-2-oxo-1(2h)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester
CAS	147126-75-8
EINECS	938-073-4
InChI	InChI=1/C18H26FN3O4S/c1-9(2)11-5-4-10(3)6-13(11)25-16(23)17-26-14(8-27-17)22-7-12(19)15(20)21-18(22)24/h7,9-11,13-14,17H,4-6,8H2,1-3H3,(H2,20,21,24)

5S-(5-氟胞嘧啶)-1,3-氧硫杂环戊烷-2R-甲酸薄荷醇酯 (FCME) - Physico-chemical Properties

Molecular Formula	C18H26FN3O4S
Molar Mass	399.48
Density	1.47
Melting Point	180 - 183°C (dec.)
Boling Point	508.5±60.0 °C(Predicted)
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
pKa	2.40±0.10(Predicted)
Storage Condition	Hygroscopic, Refrigerator, under inert atmosphere
Stability	Hygroscopic
Refractive Index	1.645
Physical and Chemical Properties	Density 1.47

5S-(5-氟胞嘧啶)-1,3-氧硫杂环戊烷-2R-甲酸薄荷醇酯 (FCME) - Introduction

(2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxylic acid menthyl ester (FCME), also known as APFO(Ammonium Perfluorononanoate), is a chemical substance. The following is an introduction to its properties, uses, preparation methods and safety information:

1. Nature:
-Appearance: colorless liquid
-Molecular formula: C14H17F5N2O4S
-Molecular weight: 410.36g/mol
-Melting point:-2 ℃
-Boiling point: 180-190 ℃
-Density: 1.43g/cm3

2. Use:
- APFO is mainly used as a surfactant and lubricant
-Used as a plasticizer and wetting agent in oil-proof and water-proof coatings
-Used as an oil and water repellent in the textile and paper industries
-Used as oil and water repellent in electronic products and electrical equipment
-Used as foam stabilizer in fire fighting foam

3. Preparation method:
The preparation method of APFO is complicated and generally requires a series of chemical reactions. The main steps include the fluorination of p-fluoroacetic acid, the synthesis of cyclic thiourea, the synthesis of fluorothiopyruvic acid, the synthesis of aminopyrimidine and the final esterification reaction. The specific synthesis process needs to be controlled by specific conditions and reagents in the chemical laboratory.

4. Safety Information:
- APFO is generally relatively safe under normal use and storage conditions, but the following matters still need to be paid attention:
-Avoid inhalation, contact with skin and ingestion
-Avoid contact with oxidizing agents
-Avoid contact with strong acids, alkalis and metal powders
-Wear appropriate protective equipment such as gloves, safety glasses and protective clothing when using
-Pay attention to compliance with relevant regulations and safe operating procedures during handling and storage
-In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical assistance

These are about the properties, uses of (2S,5R)-5-Fluoro cytosine-1-yl-[1,3]-oxathiolane-2-carboxylic acid menthyl ester (FCME), basic introduction of preparation methods and safety information. When using and handling the chemical, Please strictly follow the relevant safety procedures.

Last Update：2024-04-10 22:29:15